Kupffer Cells Mediate Leptin-Induced Liver Fibrosis
نویسندگان
چکیده
منابع مشابه
Kupffer cells mediate leptin-induced liver fibrosis.
BACKGROUND & AIMS Leptin has profibrogenic effects in liver, although the mechanisms of this process are unclear. We sought to elucidate the direct and indirect effects of leptin on hepatic stellate cells (HSCs). METHODS HSCs from Sprague-Dawley rats were exposed to leptin and expression of collagen-I, tissue inhibitor of matrix metalloproteinases-1 (TIMP1), transforming growth factor beta1 (...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2009
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2009.04.011